فوق دکترا درجراحی کلیه ومجاری ادرار ازدانشکده پزشکی دانشگاه تهران و عضو انجمن ارولوژی ایران
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كاربر میهمان خوش آمدید
Sat 16 Jul 2011

In The Name Of God

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The Books  That Authored And Translated by

Mohammad Hezarkhani

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ارسال شده توسط دکتر محمد هزارخانی در ساعت 3:32 بعد از ظهر
Fri 24 Oct 2014

 

1 Daily aspirin use and prostate cancer–specific mortality in a large cohort of men with nonmetastatic prostate cancer Journal of Clinical Oncology, October 24, 2014   

 

2 National trends in the management of low and intermediate risk prostate cancer in the United States The Journal of Urology, October 24, 2014   

 

3 Lymphovascular invasion is significantly associated with biochemical relapse after radical prostatectomy even in patients with pT2N0 negative resection margin Prostate Cancer & Prostatic Diseases, October 24, 2014   

 

4 Improved outcomes owing to high intensity focused ultrasound devices for the treatment of patients with localized prostate cancer The Journal of Urology, October 24, 2014   

 

5 Psychosocial adjustments in patients with prostate cancer from pre-diagnosis to 6 months post-treatment International Journal of Nursing Practice, October 24, 2014   

 

6 Transurethral intraprostatic injection of botulinum toxin type a for the treatment of chronic prostatitis/chronic pelvic pain syndrome: Results of a prospective pilot double-blind and randomized placebo-controlled study BJU International, October 24, 2014    

 

7 Epithelial–mesenchymal transition in prostate cancer is associated with quantifiable changes in nuclear structure The Prostate, October 24, 2014   

 

8 Inhibition of TGF-β/SMADs Signal by MiR-155 is Involved in Arsenic Trioxide-induced Anti-angiogenesis in Prostate Cancer Cancer Science, October 24, 2014   

 

9 Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm2: Correlation with Gleason score and repeatability of region of interest analysis Magnetic Resonance in Medicine, October 24, 2014

 

10 Bimodal pattern of the impact of body mass index on cancer-specific survival of upper urinary tract urothelial carcinoma patients Anticancer Research, October 24, 2014   

 

11 The comparison of minimally invasive percutaneous nephrolithotomy and retrograde intrarenal surgery for stones larger than 2 cm in patients with a solitary kidney: A matched-pair analysis World Journal of Urology, October 24, 2014    

 

12 Pelvic floor muscle function is an independent predictor of outcome after retrourethral transobturator male sling procedure World Journal of Urology, October 24, 2014  

 

13 New hope for potential prostate cancer patients UAB Medicine, October 24, 2014

 

14 Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer Clinical Cancer Research, October 24, 2014    

 

15 PCNL in the twenty-first century: Role of Microperc, Miniperc, and Ultraminiperc World Journal of Urology, October 24, 2014

 

16 Scrotal calculi in clinical practice and their role in scrotal pain: A prospective study Journal of Clinical Ultrasound, October 24, 2014  

 

17 Eculizumab and splenectomy as salvage therapy for severe antibody-mediated rejection after HLA-incompatible kidney transplantation Transplantation, October 24, 2014

 

18 Mechanisms of translational repression of the Smcp mRNA in round spermatids Reproduction, October 24, 2014

 

19 Primary ectopic atypical meningioma in the renal hilum: a case report Full Text BMC Cancer, October 24, 2014

 

20 Metastatic renal cell carcinoma to the urinary bladder: A report of 11 cases American Journal of Surgical Pathology , October 24, 2014

ارسال شده توسط دکتر محمد هزارخانی در ساعت 9:11 بعد از ظهر |
Thu 23 Oct 2014

 

Urology News

Oct.23,2014

 

1 Particle radiotherapy for prostate cancer International Journal of Urology, October 23, 2014

 

2 Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk World Journal of Surgical Oncology, October 23, 2014  

 

3 Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes The Prostate, October 23, 2014

 

4 Quality of life improvement for patients treated with degarelix versus leuprorelin in advanced prostate cancer The Journal of Urology, October 23, 2014   

 

5 Predictive value of magnetic resonance imaging determined tumor contact length for extra-capsular extension of prostate cancer The Journal of Urology, October 23, 2014   

 

6 A systematic review of experience of 180w xps greenlight laser vaporization of the prostate in 1640 men BJU International, October 23, 2014    

 

7 Clinical utility of 18F-fluorocholine PET-CT in biochemical relapse of prostate cancer after radical treatment: Results of a multicentre study BJU International, October 23, 2014

 

8 Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: A prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial The Lancet Oncology, October 23, 2014    

 

9 Risk of acute myocardial infarction after androgen deprivation therapy for prostate cancer in the Chinese population BJU International, October 23, 2014   

 

10 Nocturnal enuresis is associated with moderate-to-severe obstructive sleep apnea in children with snoring Pediatric Research, October 23, 2014    

 

11 International multicenter psychometric evaluation of patient reported outcome data for the treatment of Peyronie's disease BJU International, October 23, 2014   

 

12 Development of the lymphoedema genito-urinary cancer questionnaire British Journal of Nursing, October 23, 2014

 

13 Mechanistic analysis of nonoxygenated hypothermic machine perfusions protection on warm ischemic kidney uncovers greater enos phosphorylation and vasodilation American Journal of Transplantation, October 23, 2014  

 

14 Diarrhea after kidney transplantation: a new look at a frequent symptom Transplantation, October 23, 2014    

 

15 A systematic review of the use of rituximab for desensitization in renal transplantation Transplantation, October 23, 2014    

 

16 Aluminum content of human semen: Implications for semen quality Reproductive Toxicology, October 23, 2014

 

17 Pheochromocytoma as the first manifestation of MEN2A with RET mutation S891A: report of a case Surgery Today, October 23, 2014    

 

18 Retraction-related acute liver failure after urological laparoscopic surgery Current Urology, October 23, 2014

 

19 Recurrent 2,8-Dihydroxyadenine nephropathy: A rare but preventable cause of renal allograft failure American Journal of Transplantation, October 23, 2014    

 

20 Elective urological surgery following coronary stent implantation: to whom, how to do it? Current Urology, October 23, 2014   

ارسال شده توسط دکتر محمد هزارخانی در ساعت 4:54 بعد از ظهر |
Tue 21 Oct 2014

 

Oct.21.2014

1 Healthy Lifestyle Behaviors of Breast Cancer Survivors Clinical Nursing Research, October 21, 2014  

 

2 Is there a relationship between endometrial polyps and obesity, diabetes mellitus, hypertension? Archives of Gynecology and Obstetrics, October 21, 2014

 

3 Use of medical, surgical and complementary treatments among women with fibroids European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014

 

4 Identification of women at high risk for severe perineal lacerations European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014  

 

5 Calcitonin gene- and parathyroid hormone-related peptides in normotensive and preeclamptic pregnancies: A nested case-control study Archives of Gynecology and Obstetrics, October 21, 2014    

 

6 Adherence to healthy lifestyle and risk of gestational diabetes mellitus: prospective cohort study BMJ, October 21, 2014

 

7 The prevention and treatment of postpartum haemorrhage: What do we know, and where do we go to next? BJOG: An International Journal of Obstetrics and Gynaecology, October 21, 2014

 

8 Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: A meta-analysis European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014   

 

9 Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014

 

10 Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men Journal of Assisted Reproduction and Genetics, October 21, 2014

 

11 Effect of implementation of the mass breast cancer screening programme in older women in the Netherlands: population based study BMJ, October 21, 2014  

 

12 DNA Methylation status of key cell cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors Clinical Cancer Research, October 21, 2014

 

13 The contribution of unimproved water and toilet facilities to pregnancy-related mortality in Afghanistan: analysis of the Afghan Mortality Survey Tropical Medicine & International Health, October 21, 2014  

 

14 Predicting breast tumor response to neoadjuvant chemotherapy with Diffuse Optical Spectroscopic Tomography prior to treatment Clinical Cancer Research, October 21, 2014

 

15 Early origins of adult disease: Low birth weight and vascular remodelling Atherosclerosis, October 21, 2014

 

16 Serum anti-Mullerian hormone levels across different ethnic groups: A cross-sectional study BJOG: An International Journal of Obstetrics and Gynaecology, October 21, 2014

 

17 Simultaneous changes of magnetic resonance diffusion-weighted imaging and pathological microstructure in locally advanced cervical cancer caused by neoadjuvant chemotherapy Journal of Magnetic Resonance Imaging, October 21, 2014  

 

18 Morphological and immunohistochemical pattern of tubo-ovarian dysplasia and serous tubal intraepithelial carcinoma European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014    

 

19 Single incision sling (Ajust) for the treatment of female stress urinary incontinence: 2-year follow-up European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014  

 

20 Borderline ovarian tumor in women aged ≥65 years: Impact on recurrence and survival European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014

ارسال شده توسط دکتر محمد هزارخانی در ساعت 7:59 بعد از ظهر |
Tue 21 Oct 2014

 

Oct.21.2014

1 Diethylstilboestrol (1 mg) in the management of castration-resistant prostate cancer Urologia Internationalis, October 21, 2014   

 

2 Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly Full Text European Urology, October 21, 2014    

 

3 Patterns of repeat prostate biopsy utilization in contemporary clinical practice The Journal of Urology, October 21, 2014

 

4 Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302) Full Text European Urology, October 21, 2014   

 

5 The cistrome and gene signature of androgen receptor splice variants in castration-resistant prostate cancer cells The Journal of Urology, October 21, 2014    

 

6 Family history in the Finnish Prostate Cancer Screening Trial International Journal of Cancer, October 21, 2014  

 

7 Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: evidence from a randomized controlled trial Archives of Physical Medicine and Rehabilitation, October 21, 2014   

 

8 AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy Tumor Biology, October 21, 2014    

 

9 Avoiding and managing vascular injury during robotic-assisted radical prostatectomy Therapeutic Advances in Urology, October 21, 2014

 

10 Phase 2 trial of neoadjuvant axitinib in patients with locally advanced nonmetastatic clear cell renal cell carcinoma European Urology, October 21, 2014    

 

11 The potential role of stem cells in the treatment of urinary incontinence Therapeutic Advances in Urology, October 21, 2014

 

12 Association between predonation serum uric acid concentration and change in renal function after living kidney donation in women Internal Medicine Journal, October 21, 2014

 

13 Surgical Technique for Laparoscopic Kidney Donation Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie, October 21, 2014

 

14 Single incision sling (Ajust) for the treatment of female stress urinary incontinence: 2-year follow-up European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014  

 

15 Intracytoplasmic morphologically selected sperm injection results in improved clinical outcomes in couples with previous ICSI failures or male factor infertility: A meta-analysis European Journal of Obstetrics & Gynecology and Reproductive Biology, October 21, 2014

 

16 Fetal diagnosis of testicular torsion: What shall we tell the parents? Prenatal Diagnosis, October 21, 2014

 

17 Depression of HspA2 in human testis is associated with spermatogenic impairment and fertilization rate in ICSI treatment for azoospermic individuals Journal of Assisted Reproduction and Genetics, October 21, 2014

 

18 Relationship between absence of annulus and asthenozoospermia in Iranian men Journal of Assisted Reproduction and Genetics, October 21, 2014   

 

19 Surgical management of early and late ureteral complications after renal transplantation: techniques and outcomes Clinical Transplantation, October 21, 2014  

 

20 Does presumed consent save lives? Evidence from Europe Health Economics, October 21, 2014   

Source:MDLINX

ارسال شده توسط دکتر محمد هزارخانی در ساعت 2:40 بعد از ظهر |
Mon 20 Oct 2014

Urology news  Oct.20.2014

Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer

June Escara-Wilke1, Jill M. Keller1, Kathleen M. Woods Ignatoski1,†, Gregory Shelley1, Atsushi Mizokami2, Jian Zhang3, Miranda L Yeung4, Kam C. Yeung4 andEvan T. Keller1,*

 18 OCT 2014/DOI: 10.1002/pros.22915.

BACKGROUND

Raf kinase inhibitor protein (RKIP) has been shown to act as a metastasis suppressor gene in multiple models of cancer. Loss of RKIP expression promotes invasion and metastasis in cell transplantation animal models. However, it is unknown if RKIP expression can impact the progression of cancer in an autochthonous model of cancer. The goal of this study was to determine if loss of RKIP expression in a genetic mouse model of prostate cancer (PCa) impacts metastasis.

METHODS

Endogenous RKIP expression was measured in the primary tumors and metastases of transgenic adenocarcinoma of the mouse prostate (TRAMP+) mice. RKIP knockout mice (RKIP−/−) were crossbred with (TRAMP+) mice to create RKIP−/−TRAMP+ mice. Mice were euthanized at 10, 20, and 30 weeks for evaluation of primary and metastatic tumor development. To determine if loss of RKIP alone promotes metastasis, RKIP was knocked down in the low metastatic LNCaP prostate cancer cell line.

RESULTS

Endogenous RKIP expression decreased in TRAMP+ mice as tumors progressed. Primary tumors developed earlier in RKIP−/−TRAMP+ compared to TRAMP+ mice. At 30 weeks of age, distant metastases were identified only the RKIP−/−TRAMP+ mice. While prostate epithelial cell proliferation rates were higher at 10 and 20 weeks in RKIP−/−TRAMP+ compared to TRAMP+ mice, by 30 weeks there was no difference. Apoptosis rates in both groups were similar at all timepoints. Decreased RKIP expression did not impact the metastatic rate of LNCaP in an orthotopic PCa model.

CONCLUSIONS

These results demonstrate that loss of RKIP decreases latency of tumor development and promotes distant metastasis in the TRAMP mouse model in the context of a pro-metastatic background; but loss of RKIP alone is insufficient to promote metastasis. These findings suggest that in addition to its known metastasis suppressor activity, RKIP may promote tumor progression through enhancing tumor initiation. Prostate © 2014 Wiley Periodicals, Inc.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 9:45 بعد از ظهر |
Mon 20 Oct 2014

 

Oct.20.2014

Smoking Raises Prostate Cancer Death Risk

Aspirin May Reduce Risk of Aggressive Prostate Cancer

Neuroendocrine (Small-Cell) Carcinomas: Why They Teach Us Essential Lessons About Prostate Cancer.

Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer

ADDENDUM: Increased Akt Signaling Resulting from the Loss of Androgen Responsiveness in Prostate Cancer. Dulinska-Litewka J, McCubrey JA, Laidler P. Curr. Med. Chem., 2013, 20(1), 144-157.

Role of miRNA Let-7 and Its Major Targets in Prostate Cancer.

Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations

A Pilot Study of Estradiol Followed by Exemestane for Reversing Endocrine Resistance in Postmenopausal Women With Hormone Receptor-Positive Metastatic Breast Cancer.

TGF-β1 mediates the radiation response of prostate cancer

Androstenedione is the preferred androgen source in hormone refractory prostate cancer-response.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 9:34 بعد از ظهر |
Mon 20 Oct 2014

Research news

Oct.20.2014

Rachid Safi1, Erik R. Nelson1, Satish K. Chitneni2, Katherine J. Franz3, Daniel J. George4, Michael R. Zalutsky2, and Donald P. McDonnell1,*1Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina. 2Department of Radiology, Duke University, Durham, North Carolina. 3Department of Chemistry, Duke University, Durham, North Carolina. 4Divisions of Medical Oncology and Urology, Duke University, Durham, North Carolina.

Previously published reports indicate that serum copper levels are elevated in patients with prostate cancer and that increased copper uptake can be used as a means to image prostate tumors. It is unclear, however, to what extent copper is required for prostate cancer cell function as we observed only modest effects of chelation strategies on the growth of these cells in vitro.

With the goal of exploiting prostate cancer cell proclivity for copper uptake, we developed a “conditional lethal” screen to identify compounds whose cytotoxic actions were manifested in a copper-dependent manner. Emerging from this screen was a series of dithiocarbamates, which, when complexed with copper, induced reactive oxygen species–dependent apoptosis of malignant, but not normal, prostate cells. One of the dithiocarbamates identified, disulfiram (DSF), is an FDA-approved drug that has previously yielded disappointing results in clinical trials in patients with recurrent prostate cancer.

Prostate cancer cells self-destruct when a copper-activated drug is delivered to the infected cells, research finds

Source: James Heilman, MD / Wikimedia Commons

Prostate cancer cell growth reduced when a copper-activated drug is used, research suggests

 Similarly, in our studies, DSF alone had a minimal effect on the growth of prostate cancer tumors when propagated as xenografts. However, when DSF was coadministered with copper, a very dramatic inhibition of tumor growth in models of hormone-sensitive and of castrate-resistant disease was observed. Furthermore, we determined that prostate cancer cells express high levels of CTR1, the primary copper transporter, and additional chaperones that are required to maintain intracellular copper homeostasis. The expression levels of most of these proteins are increased further upon treatment of androgen receptor (AR)–positive prostate cancer cell lines with androgens. Not surprisingly, robust CTR1-dependent uptake of copper into prostate cancer cells was observed, an activity that was accentuated by activation of AR.

Given these data linking AR to intracellular copper uptake, we believe that dithiocarbamate/copper complexes are likely to be effective for the treatment of patients with prostate cancer whose disease is resistant to classical androgen ablation therapies.

Cancer Res; 74(20); 5819–31. ©2014 AACR. July 19, 2014.

©2014 American Association for Cancer Research.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 11:45 قبل از ظهر |
Mon 20 Oct 2014

 

Oct.20.2014

Presence of enzyme may worsen effects of spinal cord injury and impair long-term recovery

Traumatic spinal cord injury (SCI) is a devastating condition with few treatment options. Studies show that damage to the barrier separating blood from the spinal cord can contribute to the neurologic deficits that arise secondary to the initial trauma. Through...

Drexel study questions 21-day quarantine period for Ebola

As medical personnel and public health officials are responding to the first reported cases of Ebola Virus in the United States, many of the safety and treatment procedures for treating...

Light-activated drug could reduce side effects of diabetes medication

Scientists have created a drug for type 2 diabetes that is switched on by blue light, which they hope will improve treatment of the disease.

Researchers reveal lung cancer can stay hidden for over 20 years

UK scientists have discovered that lung cancers can lie dormant for over 20 years before suddenly turning into an aggressive form of the disease, according to a study published in...

College athletes in contact sports more likely to carry MRSA, study finds

Even if they don't show signs of infection, college athletes who play football, soccer and other contact sports are more likely to carry the superbug methicillin-resistant Staphylococcus aureus (MRSA), suggests...

Similar but different: New discovery for degenerative disease

Researchers from the University of Melbourne have established how two diseases that present in similar ways are in fact quite different.

Hormone loss could be involved in colon cancer

Some cancers, like breast and prostate cancer, are driven by hormones such as estrogen and testosterone, but to date, there are none that are driven by the lack of a...

New increase in antimicrobial use in animals in Denmark

Antimicrobial usage in animals in Denmark continued to increase in 2013 -- mainly due to an increased use in pigs. However, antimicrobial use in pigs is still 12% lower than...

New genetic variants associated with coffee drinking

A new, large-scale study has identified six new genetic variants associated with habitual coffee drinking. The genome-wide meta-analysis, led by Harvard School of Public Health and Brigham and Women's Hospital...

New 'lab-on-a-chip' could revolutionize early diagnosis of cancer

Scientists have been laboring to detect cancer and a host of other diseases in people using promising new biomarkers called "exosomes." Indeed, Popular Science magazine named exosome-based cancer diagnostics one...

Testosterone promotes prostate cancer in rats

A researcher who found that testosterone raised the risk of prostate tumors and exacerbated the effects of carcinogenic chemical exposure in rats is urging caution in prescribing testosterone therapy to...

Scientists opens black box on bacterial growth in cystic fibrosis lung infection

Researchers from the University of Copenhagen have shown for the first time how bacteria can grow directly in the lungs of Cystic fibrosis patients, giving them the opportunity to get tremendous insights into bacteria behavior and growth in chronic infections.

Chemical derived from broccoli sprouts shows promise in treating autism

Results of a small clinical trial suggest that a chemical derived from broccoli sprouts -- and best known for claims that it can help prevent certain cancers -- may ease...

Oral capsule as effective as invasive procedures for delivery of fecal transplant

A noninvasive method of delivering a promising therapy for persistent Clostridium difficile (C. difficile) infection appears to be as effective as treatment via colonoscopy or through a nasogastric tube. In...

All that glitters is... slimy? Gold nanoparticles measure the stickiness of snot

Some people might consider mucus an icky bodily secretion best left wrapped in a tissue, but to a group of researchers from the University of North Carolina at Chapel Hill,...

Bowel cancer risk reduced by adopting multiple healthy behaviors

Adoption of a combination of five key healthy behaviors is associated with a reduction in the risk of developing bowel cancer. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke...

Cellular 'power grid' failure triggers abnormal heart rhythms after a heart attack

Heart attack survivors often experience dangerous heart rhythm disturbances during treatment designed to restore blood flow to the injured heart muscle, a common and confounding complication of an otherwise lifesaving...

Grapefruit juice stems weight gain in mice fed a high-fat diet, study finds

Fad diets come and go, but might there be something to the ones that involve consuming grapefruit and grapefruit juice? New research at the University of California, Berkeley, suggests that...

UPMC programs to improve hand hygiene reduced infections, increased compliance

UPMC Presbyterian Hospital's infection prevention teams have improved hand washing and sanitizing compliance at the hospital to nearly 100 percent among clinical staff through accountability and educational measures. In a...

Intracranial stents: More strokes than with drug treatment alone

The risk of having another stroke is higher if patients, after dilation of their blood vessels in the brain, not only receive clot-inhibiting drugs, but also have small tubes called...

Sugar linked to memory problems in adolescent rats

Studying rats as model subjects, scientists found that adolescents were at an increased risk of suffering negative health effects from sugar-sweetened beverage consumption.

World's first child born after uterus transplantation

In a ground-breaking research project at the University of Gothenburg, seven Swedish women have had embryos reintroduced after receiving wombs from living donors. Now the first transplanted woman has delivered..

© 2014 (e) Science News

ارسال شده توسط دکتر محمد هزارخانی در ساعت 11:0 قبل از ظهر |
Mon 20 Oct 2014

Urology-Research  news

Qi-Xiang Song, Christopher J. Chermansky, Lori A. Birder, Longkun Li & Margot S. Damaser /Nature Reviews Urology11,579–588(2014)doi:10.1038/nrurol.2014.244

16 September 2014

Urinary incontinence adversely affects quality of life and results in an increased financial burden for the elderly. Accumulating evidence suggests a connection between neurotrophins, such as brain-derived neurotrophic factor (BDNF), and lower urinary tract function, particularly with regard to normal physiological function and the pathophysiological mechanisms of stress urinary incontinence (SUI) and bladder pain syndrome/interstitial cystitis (BPS/IC).

Figure 1: The neuromodulatory effects of BDNF in the dorsal root ganglion, in relation to lower urinary tract function.

The neuromodulatory effects of BDNF in the dorsal root ganglion, in relation to lower urinary tract function.

BDNF expression is mediated by the NGF-dependent PI3K–Akt pathway. Expression of NMDA and AMPA receptors is regulated by the Ras–MAPK pathway, and modulated by BDNF–Trk-B signalling. Abbreviations: Akt, protein kinase B; AMPA, α-amino-…

Figure 2: Schematic diagram of the interaction between BDNF and glutamate receptors.

Schematic diagram of the interaction between BDNF and glutamate receptors.

BDNF binds to the extracellular domain of Trk-B receptor, activating an intracellular signalling cascade that includes PI3K–Akt, Ras–MAPK and the PLCγ–Ca2+ pathways. a | BDNF can facilitate NMDA receptor and AMPA receptor signalling th

The interaction between BDNF and glutamate receptors affects both bladder and external urethral sphincter function during micturition. Clinical findings indicate reduced BDNF levels in antepartum and postpartum women, potentially correlating with postpartum SUI. Experiments with animal models demonstrate that BDNF is decreased after simulated childbirth injury, thereby impeding the recovery of injured nerves and the restoration of continence.

Figure 3: BDNF regulation of lower urinary tract function.

BDNF regulation of lower urinary tract function.

BDNF facilitates PN function and could increase EUS muscle tone (1). Retrograde transport of BDNF from the bladder to the DRG has a role in DOA (2). BDNF-mediated glutamate signalling participates in bladder and EUS contractility (3).…

Treatment with exogenous BDNF facilitates neural recovery and the restoration of continence. Serotonin and noradrenaline reuptake inhibitors, used to treat both depression and SUI, result in enhanced BDNF levels. Understanding the neurophysiological roles of BDNF in maintaining normal urinary function and in the pathogenesis of SUI and BPS/IC could lead to future therapies based on these mechanisms.

ارسال شده توسط دکتر محمد هزارخانی در ساعت 10:41 قبل از ظهر |